its official: i'm a mutant MTHFR! 2 funky genes = 2 critical enzymes impaired

its official.  i tested positive for a 2nd gene flaw:   

i am a MTH FR mutant!  

OR

i am a mutant MTH FR! 

the first is more correct, the second rings better for a tshirt  ;)

hope the trump regime won't form a 'mutant deportation force' to round us up  ;)

actually, 50% of us will test positive for at least 1 gene variant so the tshirt line aka any product line could make a few new millionaires!  i have two, so the odds for that drop to 25%, then i have a higher risk combination which is more rare - so that may narrow down to half of that (not enough data yet).

*i share my bloodwork and symptoms not for any pity, but as i strongly believe everyone, anyone who has any issues be it acne or allergies, tooth sensitivity, pain all over, if you took any drugs, literally everyone would benefit from taking the same battery of tests i am.  to that end, it made sense to setup a blog for all the documents i move through with highlights i make since i started this trip:  http://bloodposture.blogspot.com/

i got my results on 3/22 (a number used by the order of skull and bones no less).  here are my efforts at relating what i learn as i go, as close to real-time, as accurately and succinctly as possible (its not easy)...

1st short summary (attempt at simplified highlights)

i have two havoc-wreaking genes that are flawed/distorted aka 'mutated'.  they share some commonality, both restrict the production of key active enzymes that are key cofactors in keeping various systems healthy, optimized and energized.

i got the MTHFR gene/enzyme from one or both parents (dont know yet) so at least one parent inherited the same issues, as might my siblings and their kids.  the MTHFR and the gene related to P5P were both referenced in the government abstract that gave me all i needed to know to figure out what leads to follow to identify what's been going on underneath the hood my entire life.  and indeed these two gene/enzyme issues spell it out entirely.

everyone has a 50/50 chance at some variant of the MTHFR mutation.  

if you have Morton's Foot:  a) you have a P5P-impaired gene AND  b) odds are high you have MTHFR too.

2nd short summary

i got two genes that impair adequate production and function of two key enzymes.  as each one is involved in some 100+ key processes, this dysfunction blocks/obscures key pathways to ever enjoying optimum health and could well be the root cause of many issues disorders, diseases and a hundred symptoms incl all of mine.

like anyone with Morton's Foot, i've got a gene that can't make enough P5P enzyme out of B6, but i also have another gene that can't make enough 5MTHF enzyme from B9 aka two key enzyme conversions are impaired.  these are two main roots of all past/future/present health hurdles and every obscure symptom i experience.

these enzyme deficiencies/dysfunctions equate a lifetime of unchecked slow-poisoning since the womb, pose multiple roadblocks to optimum health.  they fail to feed neurotransmitters and build nerve-heart-immune strength and render many systems suboptimal and imbalanced, 35% less functional 35% less energy, wasting what little energy it manages to produce, straining to perform its key functions at 100% but failing to keep up.

these distorted genes/enzymes screw up all kinds of inter-dependent systems, instead of feeding key nutrients to cells, tissue, systems, it enables free radicals to attack/damage them.  and the body is unable to eliminate toxins/detox, so heavy metals, free radicals, and toxic elements are allowed to accumulate over a lifetime.  

any organism living in a state of relentless poisoning aka chronic chemical imbalance is tiptoeing on eggshells.  it could make these folks profoundly sensitive 'allergic' to any number of things incl. strong perfumes, bright lights, loud noises, hot/cold temperatures, teasing/ridicule, environmental neurotoxins like mold, chlorine, fluoride, electromagnetic fields, radiation, etc.  already under duress, anything could push them over the edge.

across a lifetime, this perpetual stress, total system duress and inflammation which literally brings the person down logically causes a biochemical-related 'depression', this is inevitably outwardly expressed emotionally as impatience/irritability and edginess/reactionary and frustration/anxiety/depression.  

like cornered animals, they may feel often trapped by any number of things i.e. by injuries, relationships, expectations, 'what people think' and trapped animals may ultimately lash out with the slightest agitation.

if always coping with duress/dysfunction, living healthy balanced lives with a healthy outlook/demeanor, could be a tall order and a grand achievement for some.  coping with so many issues and 24/7 toxicity for decades cant be very pleasant, it's got to be a buzzkill, messes with your personality and infects your relationships.

am i describing myself, or did i just describe half the folks i've ever known?  its a 50/50 you have the MTHFR gene impairment, similar odds for the P5P gene.  even if you have none, you may still have excess toxicity.

going a bit deeper 

both mutations screw with the 'methylation cycle' by impairing the body's ability to create key active enzymes from vitamins B6 and B9 that help us detoxify, convert food to energy, support auto-immune function, etc..  it puts various roadblocks on key biochemical pathways that choke your ability to be healthy - putting you at risk for a very long list of issues - this is the root of many odd symptom across your whole life, be it bedwetting or attention deficit, acne to memory issues, allergies to backpain, migraines, vertigo, hearing loss/ringing, tooth sensitivities, loss of grip strength, on and on.

all the havoc made by these genes can infer a higher risk of cancer, stroke, autoimmunity, nerve, thyroid and heart disease, fibromyalgia, chronic fatigue, etc (the list is long and absorbs long B12 and candida lists as this is the root to both).

[grabbed on the fly from somewhere]:

• if P5P is lacking, then the methylation process will be impeded. 
• P5P helps drive the methylation cycle, creating neurotransmitters serotonin, dopamine and norepinephrine
• normal recycling of homocysteine to methionine relies on 5-MTHF
• impaired MTHFR function has multiple negative impacts on DNA synthesis and repair, embryonic development, neurotransmitter synthesis, and cardiovascular risk factors.   
• the role of MTHFR in health and disease has been the subject of intense research in recent years, and this work is beginning to influence clinical practice. in many ways, MTHFR function provides important clues to the risk of developing particular diseases, and to the etiology of seemingly unexplained or unexpected symptom patterns.

methylation is a central and vital process in the whole body and if this gets disturbed, all sorts of things go wrong.  it is a biochemical process that builds neurotransmitters like dopamine and serotonin, produces energy, processes hormones, builds immune cells, turns genes on and off, synthesizes DNA, produces the protective coating on your nerves and transforms toxins into safer substances. it happens in all the cells of your body distributing methyl (CH3) groups to as many as 50 or more other chemical processes in the body.  that's why you can't be vibrantly healthy if methylation isn't running smoothly in your body. it's also why the symptom list associated with methylation disfunction is so long.  [grabbed it from somewhere] 

P5P works with other B co-enzymes to turn nutrients into energy.   the body cant produce enough P5P enzymes from B6 to support/drive the methylation processes and Hcy metabolism - can't convert enough Hcy toxic amino acids floating around into energy the body can use, leaving the organism in a chronic toxic state, fostering slow nerve damage by free radicals, across a lifetime.

in the process, low P5P strains/depletes other Bs (B2, B12 -as in my case) which snowballs into other chemical imbalances cascading issues to every cell across all systems, exhibiting a myriad of symptoms separated into groups and misdiagnosed with wrong labels thus mistreated.  the tests i lined up confirmed all of this to be accurate. 

last summaries before we get you tested

(forgive any repeat - it is kinda inevitable)

so both gene flaws result in low Bs and high Hcy among various other problems aka slow-poisoning since the womb, one of them also stunts the growth of the big toe bones.  MF is a stunted toe growth caused by the P5P-deficiency/gene. 

these gene/enzyme issues are keystones to all kinds of issues physical, behavioral, emotional, mental that dictate not just our bodywide pains, but also determine many subtleties of mood, disposition, demeanor and sensitivities.

MF is a genetic 'deformity' 15-30% of us visibly have (by my own observations of sandals in a sauna 9 people full, where i could see maybe 6 sets of feet, 3 of us had stubby first toes.  based on that casual survey, 30-40% is what i noticed.  i read that most with MF do not have the visibly 'longer' 2nd toe.  if true, that could easily stretch the prevalence to half of the population.

the MTHFR gene contributes to parallel hurdles.  MTHFR may be a root cause keystone that locks/unlocks the door to health.  it is linked to a wide group of diseases and disorders, symptoms and groupings.  each gene and its impaired enzyme production could be a root cause of current past future health hurdles.

high Hcy compromises our immune and nervous systems, and we are all at risk.

even if you dont have Morton's Foot, you still run a 50/50 chance at 1 variation of the MTHFR mutation (just wanna drive that point home).

one or both of these genes create key chemical imbalances in our systems.  and if you have MF, you may have both of these gene mutations.  that was the embedded message in the gov abstract announcement - its why i took the test.  if you have both, you might be more susceptible to experience a lot of hurt.

so 25% of us are genetically suboptimized/vulnerable, living in a poisonous state 24/7 our whole lives, some of us our enzymes are 70% impaired/dysfunctional, some 35%.  

i'm pretty confident of a few things...

if you have MF, your bloodwork in key ways would look similar to mine, yours and at least one parent.  all my mother's symptoms fit from osteoarthritis to back/joint pain, loss of grip-strength, loss of balance/motorskills, irritability/impatience, etc.

even if you don't have the genes or show any signs of duress, you should still go get tested as you may well have high Hcy, if not by birth, then you may have acquired it by taking rx medicines, toxic exposures, high stress, virus, infection, deficient food supply aka soil nutrients or any combination of those.  you could also acquire similar disorder disease symptoms risks and be toxic. 

note:  no illness or gene will ever make everyone sick in the same way or to the same degree.  some can be vexed by a broad array of symptoms their whole life, another might not show any signs until old, some may suddenly test positive for cancer, some just die suddenly without warning.  so let this be your warning... 

99% doctors are just obedient big pharma drug dealers in white lab coats - the clinics are factories - they regurgitate talking points - tow the line - they dont advocate these tests or even know about them. conventional medicine/doctors are not, by default or design, able to help us build stronger systems.  they do not have the tools or training to do so.  they're a racket.

integrative functional medicine doctors are so good, that insurance wont cover their $300/hr rate so you gotta be rich to visit them.  if you're a rich penny-pincher or working poor, to feel your best and enjoy a stronger quality of life, you'll need to find affordable micronutrients, experiment with supplementation combinations. 

the Human Genome Project gave us the chance to know what is going on in our genes before health conditions develop and better prevent illness, we can even heal the gene if we take measures to confront the problems.  so go get tested.

soon i'll get a list of the half dozen tests to take, links to best supplements, etc.