Undermethylation and Depression – Walsh Biotypes | CorePsych

snippets from two 1.5 min video clips on the referenced page on corepsych.com:

• undermethylated people include many are OCD, perfectionist, high achievers, great athletes, CEOs etc. (95% of them) but 15-20% of this group are prone to issues including low serotonin which makes them prone to depression.

• total of 5 completely different forms of biotype depression, each requires different treatment, normalized/remedied by specific nutrient therapy. 

breakdown of total cases of clinical depression in the study:

38%  Undermethylated – Histamine >70 ng/ml, low SAMe/SAH ratio, low serotonin

20%  Folate Deficiency – Overmethylation – elevated serotonin and dopamine 

17%  Copper Overload – elevated norepinephrine 

15%  Pyrrole Disorder – reduced serotonin, GABA 

5%  Toxic Overload – lead, mercury, cadmium or arsenic  

Undermethylation and Depression – Walsh Biotypes 

http://www.corepsych.com/2014/09/depression-walsh-biotypes-undermethylation/

by  Dr Charles Parker at  September 13, 2014

Undermethylation & Depression Biotypes:  – 1 of 5 Subsets

The challenge is to carefully identify the specific nutrient overloads and deficiencies possessed by an individual, and to provide treatments that normalize blood and brain levels of these chemicals with rifle shot precision. This is the essence of biochemical therapy.
~ William Walsh

Introduction – Undermethylation – WD1

Undermethylation is associated with perfectionism, strong will, high accomplishment, OCD tendencies, and seasonal allergies… more than two-thirds of persons diagnosed with a behavior or mental disorder exhibit a methylation imbalance.
~ William Walsh

Bill Walsh is a mind pioneer. This brief video describes WD1 – Walsh Depression biotype 1 [1 of 5], and will likely whet your appetite for investigating the fact that depression is more than just an appearance of sadness. Undermethylated depression will prove untreatable if not measured and addressed. I'll report for you here at CorePsych the other four as time permits.

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Important Note

A significant number of undermethylated depression patients exhibit some degree of pyrrole disorder. Many persons with this combination of imbalances exhibit high accomplishment throughout life, but report extreme internal anxiety and poor stress control along with depression . Since both undermethylation and pyrrole disorder are associated with low serotonin activity, depression is usually more severe in these cases. Our database studies indicate persons with this hybrid condition are more likely to report suicidal thoughts compared to persons with any other form of depression.¹

From appearances to measurable science – biotype laboratory neurophysiological assessments will change treatment outcomes for depression and a variety of other mind-presentations. Markers matter.  Laboratory assessments do improve predictability for challenging clinical outcomes – read: treatment failure.

Dr William Walsh: CorePsych Critical Thinker

Dr Walsh has presented his research at the American Psychiatric Association, the U.S. Senate, the National Institute of Mental Health, the Society for Neuroscience, and has been a speaker at more than 30 international conferences. He has authored more than 200 scientific articles and reports, and has five patents.

Dr Walsh has researched biomedical details for individuals previously considered as untreatable: from personality disorders to others insufficiently treatable with modern psychopharmacology. He's published research and biomedical evaluations on lost souls from murderers to those more commonplace presentations of untreatable depression and ADHD. Think: new options for treatment failure at any level of mind alteration.

If you're interested in learning more about his groundbreaking work consider attending his Walsh Research Institute meeting in Chicago Oct. 18-22, next month.

Back to refractory depression: First the video and then a brief discussion of undermethylation: ^{4, 5}

Symptoms and Traits of Undermethylation

These replicable medical findings clearly encourage more complete assessments – Summarized from Nutrient Power¹ Walsh's most recent book, with all the details of how to specifically both measure and treat this specific, easily identified form of depression. *Don't let the nutritional title trivialize your response. Read this book. Measure for methylation imbalances via whole blood histamine.

Important indicators of this syndrome include a whole blood histamine level above 70 ng/ml and a depressed SAMe/SAH ratio ⁷ in combination with key symptoms and traits including OCD tendencies, seasonal allergies and a history of perfectionism.¹

Treat the underlying undermethylation problem as it looks in your life, your offices. We now measure for these methylation issues at CorePsych.

Clinical Characteristics

Characteristics of Undermethylation – 38% of clinical depression [n – 2800]:

1. good response to SSRIs – reduced serotonin and dopamine
2. self-motivated – [read: loner]
3. low tolerance for pain
4. very strong-willed
5. high suicidal tendency
6. sparse chest leg and arm hair
7. denial of depression
8. addictiveness
9. noncompliance with therapies [read: do it yourself – DIY]
10. oppositional defiant as a child⁶

Do you see anything familiar in treatment refractory individuals you know or treat? Did the words addiction and suicide catch your attention? Do you think that non-compliance, denial, and oppositional behaviors are clinically significant?

Undermethylation Treatment Response Time³

Expect little/no improvement during the first three to four weeks, followed by steady improvement during months two to six.

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Hi Dr. Parker,

I began taking methylfolate (500mcg per day) and methyl b12 (1000 mcg per day) about a week ago and couldn't believe how amazing I felt. I struggle with depression and ADD and I felt like a fog was lifted from my brain. I also continued to take 5mg of Adderall twice per day. I continued to feel great for about two more days and then it seemed like everything slowly went downhill from there. I wasn't experiencing the same effects from the supplements. The past two days, I felt absolutely awful. The best way I can describe it is that I felt anxious, restless, apathetic, and just totally down. Do you have any idea why I might have experienced such amazing symptom relief followed by a total worsening of symptoms? Thank you!

Dr Charles Parker says:

July 20, 2016 at 9:57 AM

Kelly,
If you notice in the vids on this page you can see that methyl is good if undermethylated and folate is for overmethylation. See this podcast wherein I interview Dr Walsh on these very issues: http://corebrainjournal.com/025
cp

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Lovely! So glad you've all heard of each other — Mensah Medical is probably the best clinic us Chicagoland natives have access to in terms of a doctor who's willing to dig deeper into root causes for psychological/cognitive dysfunctions. Last summer (2013), I was conflicted between going to Mensah Medical or your practice in Virginia Beach to dig deeper and get as many informative labs ordered as possible (especially since, due to hitting rock bottom in treatment progress, i'd reached my maximum out of pocket w/ insurance for the year). I had to end up going with M.M. since insurance approved me for TMS treatment for a solid 8 or so weeks thru my local pdocs office.

I think the Walsh Biotypes are an essential methodology to include in one's constructively diagnostic toolkit, but unfortunately the two doctors I met with were hyperfocused on these main biotypes throughout my entire appointment (cost nearly a grand in the end…best 22nd birthday gift ever, said no one ever). For example, they refused to order any kind of quality NT testing amongst several others – and I had to beg for a GPL OATs, basic labcorp lyme disease, blood typing (to check for A certain type, which Walsh has plainly noted interferes with treatment outcome timeframes/expectations, IgG foods, homocysteine, and vitamin D.

Sigh. Cookie-Cuttered mindsets almost everywhere these days; so frustrating – especially for the patient who's enjoyed spending his too many semesters of medical leave from college keeping himself well-informed of current tools available to practitioners – especially the quality/variety/specificity of those few innovative laboratories out there.

Dr Charles Parker says:

November 1, 2014 at 4:21 PM

Michael,
After I've seen them [assuming you're speaking about Dr M and Dr B] in action for 5 days at the meetings I can tell you that you and I were in very good company. All of us know a piece. Reality is difficult to touch, harder to embrace. They know that Walsh piece very darn well, and few do. Without looking at your results I can say that I might, however, possibly agree with you on one point: yeast, IgG, homocysteine, would be useful. If they didn't request those they had a clear reason. Without knowing exactly what happened I can say with considerable certainty that they are much into these tests – but suspect some other variables supervened.

One other somewhat exculpatory note: devoted as I am to NT testing, with years of experience, I can tell you, even tho I'm a relative novitiate, that I have high confidence in adding the Walsh Protocol details to CorePsych and have enjoyed some very interesting and positive conversations even at this innocent level of experience. NT testing is falling quick into less importance unless easily supported by acceptable ROI.

Whatever your results, stay w your program, sometimes these matters take time. Press on. The informed win far more often then the uninformed.

Michael,
A small PS that might be of interest as I bring Dr Walsh into a video/webinar/ADHD discussion: http://corepsych.com/totallyadd-what-video
Rick Green and his crew were great fun to work with.