Abstract
Inherited or acquired hyperhomocysteinemia (HHcy) is associated with several impairments, as certain tumors, deep venous thrombosis, tube neural defects, osteoporosis, early atherosclerosis and vascular acute events (IMA, stroke, PVD), mild cognitive impairments till Alzheimer's disease (AD).
But, vascular and neuronal derangements are the most frequent HHcy-manifestations. As far as early atherosclerosis, some clinical trials demonstrated that folates and B6-12 vitamins supplementation is unable to reduce atherosclerotic lesions and cardiovascular events, even if it lowers HHcy levels.
Thus, for [early] atherosclerosis and its acute events (IMA, stroke, PVD) HHcy acts as a powerful biomarker rather than a risk factor. For that, the supplementation with folates and B vitamins to lower atherosclerotic lesions-events in hyperhomocysteinemic patients is not recommended.
On the contrary, several clinical investigations demonstrated that folates and vitamins administration is able to reduce Hcy serum levels and antagonize some mechanisms favouring neurodegenerative impairments, as mild cognitive impairment, AD and dementia.
Thus, contrarily to the atherosclerotic manifestations in hyperhomocysteinemic patients, preventive treatment with folates and B6-12 vitamins reduces Hcy concentration and could prevent or delay cognitive decline and AD.
Wolfgang Lawrence Kellner
925-448-5805 | wolf@amplifyroi.com
linkedin.com/in/wolflawrencekellner
tip: if watching videos, you can slow it down 10% with each click of S key, speed it up 10% with each click of D key, jump back 5sec with J key, jump fwd 5sec with L key, stop/start it with K key
to your health! to get started on optimizing your health/nutrition/micro-nutrition...
order your $99 DNA spit test to know all your unique gene variants: https://refer.23andme.com/s/wolf
order your $59-69 Homocysteine bloodtest AND memorize your Hcy# (6-8 is optimal)
$59 http://requestatest.com/homocysteine-testing (quest diagnostics or lab corp)
$68 https://www.healthlabs.com/homocysteine-testing (quest diagnostics or lab corp)
$69 https://www.walkinlab.com/homocyst-e-inebloodtest-plasma.html (lab corp only)
order your $25-39 Uric Acid bloodtest AND memorize your UA# (<5.0-6.0 optimal)
$27 https://www.walkinlab.com/uricacidserumtest.html (lab corp only)
$29 http://requestatest.com/uric-acid-testing# (quest diagnostics or lab corp)
$39 https://www.healthlabs.com/uric-acid-testing (quest diagnostics or lab corp)
ask your doctor to order: B2, B6, D, B9, B12
if they wont, you can order it yourself:
healthlabs, walkinlab, requestatest
optimal levels
B12 [>550 pg/ml bottomline of 'normal' in japan/europe]
COMT V158M rs4680 AG +/- COMT H62H rs4633 CT +/- VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/- MTHFR C677T rs1801133 AG +/- MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AG +/- MTRR A66G rs1801394 GG +/+ BHMT-02 rs567754 CT +/-
BHMT-08 rs651852 CT +/- CBS A360A rs1801181 AG +/- SOD2 A16V rs4880 GG +/+
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