the science is so bleeding edge new, that % impairment has shifted a bit over time, but thanks to guy behind selfhacked and selfdecode, this graphic is nonethless handy, appreciated, and easy enough to grasp vs most others...
image: https://i2.wp.com/selfhacked.com/wp-content/uploads/2016/05/mthfr-677ct-1298ac.jpg?w=869&ssl=1

677CT -/- AND 1298AC -/- = baseline normal enzyme activity
677CT -/- AND 1298AC +/- = baseline normal enzyme activity
677CT -/- AND 1298AC +/+ = 30-40% reduced enzyme activity
677CT +/- AND 1298AC -/- = 30-40% reduced enzyme activity
677CT +/- AND 1298AC +/- = 50-60% reduced enzyme activity
677CT +/+ AND 1298AC -/- = 60-70% reduced enzyme activity
677CT +/+ AND 1298AC +/- = 60-70% reduced enzyme activity
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