- To access your 23andme raw data, find instructions here. Then upload it to site(s) of your choice - various included in the list below
If you wanna focus on the genetic info that indicate methylation (especially MTHFR) ability and detox issues. But there are so many other relevant topics, such as locating relatives/ancestors for family trees, mapping your genome, locating all the research on a particular gene and more!
Here are three tools to start with. They'll provide general info, specific nutrition/supplementation insight and athletic profiling:
Please remember: Genes are not the be all end all when it comes to disease risk… the study of Epigenetics (as well as common sense) proves that your environment* acts upon your genetics and ultimately has the greatest impact on your health. You can feel empowered by that! *Environment = air, food, microbes, relationships, emotions.
- PureGenomics offers an analysis of a few key genes that affect methylation and detox. Unfortunately, they don't just give this info away- It is free, but I need to set up an account for you. Email me with your date of birth (real or fake) and I'll happily get you access!
- Athletigen provides insight about your ideal forms of exercise. This includes things like endurance, muscle type and recovery time.
- GeneticGenie provides you with both a Methylation Analysis and a Detox Profile. The former will indicate whether you need to tweak your diet and supplementation (especially to make sure you're taking the correct forms of folate and B12). The latter will help you understand how well your body can detoxify (this output is much less helpful than the methylation analysis).
- Promethease creates a report for $5. It's a mess of data, but I don't recommend it unless you're planning to dig deep.
- Livewello offers a comprehensive look at the relationship between your genetics and physical traits & disease risk (all for $19.95).
- CodeGen.eu offers "tools to help you explore your individual 1600-3000 page report: modern search, over 2000 topics, major categories, filters, favorites, social genomics." Includes "Psychological traits such as resilience, stress response, empathy, etc."
- NutraHacker has some free features: "After a short 29 question anonymous survey that contributes to research, receive a FREE detoxification and methylation analysis (examining 49 SNPs) that will help clarify your nutritional needs. You also receive a FREE placebo tendency analysis report." Full report is $23 and includes all future updates.
- Infino.me offers a good cause & some great visuals. It is "a citizen science experiment to help people lose weight, feel better, and live longer. By bringing together the right data we can understand the interactions between genetics and lifestyle for the good of science! Our tools give you an overview of the genetic risk profile of several diseases, and match you with open-access literature written about specific genetic variants."
- Enlis.com offers a free genome report, but to download it you have to hand over $40.
- GeneKnot.com allows you to "find users with similar DNA and share the experience."
If you are looking for the most popular interpretation tool, it's promethease. If you want to take it all the way and try to jump to actionability, one of my favorites is the health and longevity report by sequencing.com. One could argue that a happy medium is still left to be desired.
There are also relatively new sites, http://sequencing.com, and mygenomebox.com. which are both trying to be the app store for genomics. They already have a few apps on there, although it's still early-days. They both seem thoughtfully designed and show some promise to become more relevant for consumers in the future.
Future contenders will likely be Helix, and DNAfeed.
Here's a brief summary:
- Promethease : $5 for most reports. Most popular, but not very user-friendly.
- Livewello: $19.95. Looks at relationship between your genetics and physical traits & disease risk.
- Xcode: $23. Provides more than "23 insights" on nutrition, fitness and disease predisposition.
- CodeGen.eu: Free. Looks at over 2000 topics, major categories, and touches on social genomics. Includes "Psychological traits such as resilience, stress response, empathy".
- NutraHacker: $23. It asks you 29 questions then gives you a detox and methylation analysis that's supposed to guide your nutritional needs.
- DNAFit. £49. Provides fitness and nutrition recommendations.
- Infino.me: Free and offers a "citizen science experiment to help people lose weight, feel better, and live longer…", "gives an overview of the genetic risk profile of several diseases, and matches you with open-access literature written."
- Enlis.com: Free to view, but $40 to download. Seems to be created more for researchers.
Many of the resources the comments have listed are very helpful. However, if you are looking to get an actual protocol or recommendations on what you should take to bypass a health-relevant mutation or to get one working properly, I'd recommend seeking out a professional. Many people who try to take something to help one mutation, can end up worsening another mutation.
This is why it's important to look at not only the single mutations, but the combinations of other health-relevant mutations before attempting to supplement. It is also important not to over-do it when it comes to attempting to resolve methylation MTHFR mutations and to go slowly when starting any new supplement. Looking at one's symptoms/ health history is also important.
I am a Holistic Health Practitioner and became certified in methylation and nutrigenomics. I've had clients who before they found me, used sites like Nutra-Hacker and started taking supplements they thought would help, only for them to feel a worsening of their existing symptoms due to a lack of understanding of how each genetic pathway works. Therefore I'd issue caution for anyone who is trying to address their mutations and self-supplement. I invite you all to check out my website at holistic-healing.
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Livewello is awesome because it will give you your Health report for all the 600,000 SNPs/Genes in your raw data. It then attaches 11 resources for learning to each Gene. The App also offers free App updates for when 23andMe adds more SNPs to your raw data. Their reason for this is that people should really have information for all the Genes in their Raw Data not just some of them. That way, you and your Heallthcare Practitioner can have the benefit of all this information when creating the treatment plan.
By the way, it works with AncestryDNA and FTDNA raw data too!
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Livewello is also the only Genetics Application that comes with these free tools:
~ Gene library with thousands of free, searchable, Health Reports that husers have unlimited access to: https://livewello.com/snps/library ,
~ Health Conditions tool to get your Gene Reports based on your health issues: https://livewello.com/gwas and
~A Sandbox tool for Customized Gene Reports https://livewello.com/snps/sandbox
~ A Lifestyle Data App to guide you in your Lifestyle Changes:
https://livewello.com/data-apps/...
There's also a new Pharmacogenomics App which tells you which medications work best with your Genetics: Pharmacogenomics and Health Reports
You can read more at: About Livewello's Gene App
Some useful resources once you're done with the test and App:
How does the Livewello App work with your Genetic Raw Data?
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Check out Project Infinome : http://www.infino.me - We provide some visualizations of genetic risk.
Our reports for SNPs and their associated genes are really advanced. We indexed millions of research articles and give linkouts so you can dig deep into research findings.
It is also an open research project aimed at investigating the nature vs nurture causes of metabolic syndrome by bringing together genetics and fitness tracker data. You can link your Fitbit or Jawbone device to see how your exercise and sleep habits compare with the crowd.
Aaand … we've recently release a mobile app. It's got full compatibility with 23andMe to show you genetic results, as well as serving as a meal logging app that recognizes food from photographs.
Full disclosure: I'm the chubby genetics geek who put all this together. I'd love feedback on how to make this tool more useful.
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www.DNAFit.com for determining your optimal diet and www.athletigen.com for determining your fitness and exercise characteristics
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