Tuesday, June 27, 2017

play triplets, DNA revelations, risks and premature worry

the playboy triplets all gave birth to all daughters within two weeks of each other, gave birth to all sons similarly, it rings a little like fake news, a bit too many coincidences to not doubt it, but remarkable if true.

that article was a disappointment for me to go through 30 click-bait slides to find their DNA tests were 98% accurate minus a few % points here and there for one sister, nothing glaringly wrong or surprising.

but i thought you might say that, to which i'll just repeat what is said in every article i relay, in case you're not keeping up with them, they all make disclaimers to alleviate fears that some worry-warts may have.

they all say 'just because your genes are hardcoded xyz doesn't seal anyone's fate', doesn't even mean you will show any symptoms, get cancer, die of stroke, whatever.  

i also relayed how DNA profile includes two parts, akin to hardware vs software and how we can't really change our genetic profile 'hardware' and the predispositions encoded, but we can effect genetic 'expressions' or the software layer, largely determined by environmental factors like toxins nutrition sleep stress exercise, so we can in essence turn specific genes 'circuits' on or off through the software we can control.  that one gives folks some hope.

the disclaimers are designed for parents and worry-warts about their kids or loved ones who maybe have no symptoms at the time they chose to get their DNA tested, so shouldn't panic or go overboard.  maybe also designed for folks who rather not know what gender their kids will be before they're born or what disease they have before it cripples them, but why not know?  just as there is no harm and more benefit to knowing gender up front, so too is knowing what rx and foods we may be allergic to, that might pose issues.

my experience is opposite as i'm trying to get to the bottom of 15-30 years of annoying symptoms - some go back at least to age 16, or back to 03 and 06 sciatic attacks incl ear-ringing and noise-sensitivity, and bright light/glare and tooth sensitivity to where i now chew very gingerly even when eating soft sticky food like chocolate (and i rather not pull any more teeth if pain can be referred from elsewhere).  knee/hip/ankle pain/injuries were added to backpain after the 06 attack as was toe/ankle numbness, muscle weakness, none of which i knew before.

since 2011 i'm coping with footpain trying insoles, chestpain mistakenly assuming i was just out of shape when its more likely an allergy to particles in the air or a food or a sign of toxicity, 5+ years of dizzy blackout and blurry vision spells, high blood pressure, and now low energy low mood, chronic fatigue, loss of balance many times a day.

in trying to solve my footpain, i stumbled onto how morton's foot is the byproduct of a gene-mutation that translates to a (B6) P5P-enzyme impairment, one that stunts the growth of the toe bones causing neanderthal foot that often translates to a lifetime of posture/pain hurdles.  that hot tip is how i came across a fed nih.gov abstract that indicated an association/linked P5P with the MTHFR mutation.

after 10 years tingly/spasms in L leg started to spread to L hand, that and hypothesizing that "low energy" could be a key root symptom to chase down underlying it all is why, armed with data, i chose to start doing key bloodwork, specifically test vitamin Bs and Homocysteine that i had to order myself as no plans cover it.  

by sheer luck (or bad luck), all of it converged at the same time, but it was symptom-driven so i was able to step through the scientific process the whole way, so when my two tests came back the results were anticipated, no surprise, both out of range: high Hcy and low B2 as per MTHFr literature, which are indicators of a methylation problem.

so i already had marching orders to raise my Bs and lower my Hcy, but i wanted to not act hastily and aim to know and identify more before trying too much, so i asked for the free MTHFr test to confirm it, as a next step based on a fed gov abstract, not some snake oil article.

that's how i methodically discovered that of the 7 MTHFR combinations, i genetically was predisposed with the 2nd most severe combo that equates some 50-60% impaired enzyme production/function.  while our methylation cycle is a kingpin for energy production and for various other systems incl detox/skin/thyroid/immune to function optimally, mine has been 50% impaired over a lifetime which explains how i feel like i've been slowly disintegrating at an accelerated rate, in a lot of ways, aging faster than my own parents, when i should not be as weak as i have become, feel like the weakest link, physically/mentally, far too weak for a former athlete/marine to want to admit. 

i can not imagine a full-time 5 days/wk gig, even though i work 8hrs/day i do it at my own pace, but to grind it out at pace 9-5 looms as a lofty challenge - like it could wipe me out completely to where i'd have no energy for life aside from work sleep work sleep feeding no sidelines.

so the body is likely toxic with excess parasites/fungus/metals etc due to 50% functional energy/detox capacity.  the bright side silver lining, is that i can help the body to fix it.

since high Hcy is one of 3-4 main tests used as solid indicators of methylation functional status, it all came together, so the MTHFr confirmation was no surprise.  i already knew my functional status re MTHF before i got the confirmation that i had the related mutation.  

so my experience and discovery are the other way around.  i first confirmed i had a methylation hurdle/issue, then found out what might be the likely cause of it and my high blood pressure (and may be the root of the bulk of my symptoms of 15-30 years).

again, it's less important if you have the gene the not, and more key to know your actual functional status of your methylation cycle to know if the gene is actually expressing itself and to what degree, since genes may sometimes not express themselves at all if you're lucky or for example have godlike powers thus your nutrition is flawless, you know all your allergens and are good at avoiding them and curtailing other triggers and toxic exposures.  

aiming to get a solid baseline methylation functional status as my starting point before supplementation, i ordered a histamine test directly.  and once i have all my tests back, then any FMD functional medicine doctor would have you take them 1-2x/year to monitor progress, make adjustments as needed, which all makes sense.  

dont know which report you mean.  the one from prometheus?   interesting, but i wasn't too impressed by it.  if it worried you that i might be worried, dont worry about that.  most folks find great relief when they find out what it is they're dealing with and need to work around. 

generally i agree about worry.  its likely better to die with everyone else in a nuclear attack than survive it having to fight others with weapons for food and water, so why worry too much about EMF or WWIII or being shot at a club.  and i dont need to live long, but i'd like to live better, less issues stacking up, feel more my age, have more strength, more energy, able to work harder, be happier, less pain, etc. so for me, life isn't about how long you live but how confident/strong you live it up.

but for me its different than for you aka 75%.  you don't have the same issues contaminating your body chronically that i have lived with for decades, though you do have allergy-like symptoms and 2 stents and whatever underlying issue and dose strong rx for 20 years, yet may not share similar methylation/energy/detox hurdles that are burdensome day to day and drain energy, as you share none of my ongoing symptoms.  so its easier for you to have such an opinion.  mom shares more symptoms with me, so your SNP profile can be a kind of control group and could illustrate why you dont share these issues as well as explain things for both you and me a bit better.

and i don't have a life to live but would like to eventually feel what it's like to be happy while sober (vs intoxicated).  my heyday was impaired too, hearing issues since toddler so bad i had to fake my tests to get into the military, backpain starting after a concussion at 16, and since first memories as a toddler, called a 'serious kid' by adults, i can't recall ever not feeling blue/melancholy/reflective and self-conscious and troubled/burdened/preoccupied by something intangible.  happiness reliably fleeting, then and to this very day, all my happy memories involve intoxication thus can't be considered true 'happiness'.  

today, i can't even drink 2 pints and not feel wiped out and drive home without falling asleep.  my body simply can't take it as if internally as toxic/weak as a 90 years old.  not having the energy to go out to 'party/live/socialize' was the obvious clue that something is amiss.

so finding 'methylation' issues ('over and under') to be a leading cause of 'biological depression' (not a mental problem, a physical one) that accounts for 58% of the clinically depressed, spells it out adequately. 

all of it on a slow downhill trajectory over decades, so the energy block is worth fixing so i can 'start living' more and stand a chance at 'feeling happy' like others.

interesting. It's along the same line I wondered about, saying if all my kids were taking the test it should rightly be identical.
So, it's not 100% accurate. Making health care decisions based on findings may be more problematic, though. 
Reading thru your report I came away not any more enlightened as before, i.e. there may be a greater risk of contracting one or another disease or not. So what? Should I now spend the rest of days worrying about something that may never come to pass? Count me out! I prefer to enjoy while I can and thank the Lord for keeping me out of trouble. Beyond that I takes my chances beyond reasonable moderation. Life is too short to spend most of it worrying.
My 2 cents.
Dad 


3 hot blonde playboy triplets may be a good teaser into DNA topics, sex always sells: http://www.kiwireport.com/identical-triplets-take-dna-test-just-discover-worrying-truth





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