labwork focus: UA, LDL, HYC, Copper/Cu, Zinc/Zn, Iodine/I, vit ADEK & B2

textbook MTHFR gene expressed: labwork confirms 50% impaired methylation.

Uric Acid [4-8 mg/dL; IDEAL: <5.0]  8/2/17:  8.4 (out of range high:  optimal: <5-6)  |  4/4/19:  5.4 mg/dL   

LDH [120-250]  10/26/17: 116 U/L  = TOO LOW  |  10/23/18:  134 U/L

Homocysteine [<11.4 umol/L; IDEAL: 6-8]  8/2/17:  13.8  = TOO HIGH   |  4/4/19:  10.8 umol/L  = TOO HIGH

vit A

vit D [30-100]  8/2/17:  27-30  = TOO LOW  | 

vit E

vit K

vit B2 [6.2-39]  8/2/17:  <5.0  = TOO LOW  | 

Copper, Serum [70 - 175 mcg/dL]   10/26/17:  74 mcg/dL  = LOW END  |  4/4/19:  78 mcg/dL  = LOW END

Zinc, Plasma or Serum [60 - 130 mcg/dL]  10/26/17:  85 mcg/dL  |  4/4/19:  64 mcg/dL  = LOW END

Iodine, Serum or Plasma [52 - 109 mcg/L] n/a     |  4/4/19:  59 mcg/L  = LOW END

WBC  [3.50 - 9.90 x(10)3/uL]  10/15/17:  11.1  |  3/16/19 ER:  11.47  = HIGH

LYMPHOCYTES %  [20-40%]  10/15/17:  14.4  |  4/4/19:  12.3  = TOO LOW

On Wed, Aug 23, 2017 at 2:24 PM wolf <wolf@amplifyroi.com> wrote:

note to self (hope these motivate you to take the extra tests i did)

too high:  HCY, UA. LDH 

too low:  B2, D
low end:  B12, Mg-RBC, RBC cnt, lymphocyte cnt, hemoglobin, hematocrit

and it's probably less that I need to eat more of this, less of that, it's that what I do eat isn't getting absorbed/processed efficiently due to 50% under-methylation, 50% lower energy production, 50% detox capacity aka over-polluted system - all due to 50% MTHFR enzyme function which causes, and isn't helped by, gut microbiome imbalance aka bad bacteria/fungal dominance.  

so gut health is my primary king pin target.  i'm working my shortlist of top 10 nutritionists in gene/gut/metabolism down to the smartest/affordable 3, one in england, one in australia, one in marin, hope to pick one asap so i can get my HCY/UA down aka get rid of the gout and confidently get back to gym/soccer without damaging the joint.

to a regular doctor, those who do routine tests and tell you "all test results are normal" and who dont run the +5 tests i did, none of the borderline results raise any flags, but to functional medicine, they can be relevant.  commonly 'normal' ranges include the obese/undiagnosed population and a narrow range within 'normal' is more 'optimal' and relevant for active people with average strength and periodic athletics.

should get 'affiliate code' links to you that help credit me for future tests.

On Aug 2, 2017 12:40 PM, "wolf" <wolf@amplifyroi.com> wrote:

per textbook MTHFR, all my bloodwork confirms i have methylation issues from 4-5 different angles now, that the   thus my MTHF enzyme production and methylation pathway is 50% impaired (the 'compound heterzygous' variant has a 15% prevalence).

so now, the next step is to find a genetic nutritionist MTHFR/CBS etc practitioner to guide me with testing/protocols to take/skip, one who is also a researcher/author, who might be able to mentor should i be able to regain my energy motivation and choose to pursue this so far most interesting path of study, not just that we have it...

and i'm not sharing this out of pity, but to prove i not only have it but that it is expressed/active and causing nearly every of my 18+ symptoms incl neuropathic numbing, etc. but i share it to prove my siblings, who like my parents, have 50% similar genes, and run a high chance of having it too, maybe just a carrier inactive.  

ex. i think mom's MTHFR is also expressed hence why she has had gout, has osteoarthritis, has pains, weakness, allergies, etc. and she could holistically treat the root problem at the gene/enzyme level vs always pop pills for middle layer diagnosis that may contain folic acid, causing more problems.  

ex. it also explains dad's symptoms, his dad's lung cancer, uncle karl heinz's strokes, etc.  so my silent agenda is to get everyone tested, using me as bait.  i would like to at least know everyone's uric acid and homocysteine numbers.  

and if you don't know them because insurance wont let your doctors order them up, then i can give you links to order them directly yourself without need for doctor.

HIGH

uric acid  8.4 (out of range high:  optimal: <5-6)

homocysteine  13.8 (out of range high:  optimal: 6-8)

LDH

LOW

vit D  27-30  (out of range low:  range: 30-100)

vit B2  <5.0  (out of range low:  range: 6.2-39)

vit B12  450-598  (low:  normal range: >550 pg/ml in japan/europe)

magnesium  5.5 in range  (optimal: 6.0-6.5)

calcium  (once borderline low in ER)

red bloodcell count  (lowish plus once out of range low in ER)

lymphocytes count   (lowish plus once borderline low in ER)
hematocrit  (lowish plus once borderline low in ER)

MAY ALSO BE HIGH (per available readings and user forums)

ammonia

sulfurcopper 

histamine

lead 

mercury 

aluminum

MAY ALSO BE LOW (per available readings and user forums)

zinc

iron

p5p (methyl B6)

On Sat, Jul 22, 2017 at 10:26 AM, wolf <wolf@amplifyroi.com> wrote:

correction:  high LDL only (not HDL) and high neutrophil cnt was only in ER so pulled it from summary.  

just did CBC and uric draw that i'll add to the mix.  

On Thu, Jul 20, 2017 at 5:49 PM, wolf <wolf@amplifyroi.com> wrote:

...

due to MTHFr, COMT, CBS, MTR SNP combo, per NIH.gov docs, i'm likely low in methyl B6, high in sulfur and amonia, possibly high in metals like mercury aluminum or lead.

...

On Sun, Apr 9, 2017 at 12:08 PM, wolf <wolf@amplifyroi.com> wrote:

On Tue, Mar 21, 2017 at 6:46 PM, wolf <wolf@amplifyroi.com> wrote:

in 2016 from a day i had blurry vision blackout-grade vertigo challenges, i had a highish neutrophil and lowish lymphocyte count (indicative of yeast dominance among other things)

comparing two CBC tests 1 year apart... my lymphocyte count is borderline low or under range aka the body is barely producing adequate number of lymphocytes... which apparently has some relationship to low P5P and its ability to convert amino acids into usable proteins.

so far, i'm inadequate/low in neutrophil count, B12, B2 and P5P

On Tue, Mar 21, 2017 at 5:54 PM, wolf <wolf@amplifyroi.com> wrote:

following Amy Myer's lead/hint/clue:

1. A low white blood cell count (WBC) has been associated with yeast overgrowth as well as 

2. a pattern of high neutrophil and low lymphocyte count. 

• 54 to 62 percent neutrophils  (58.6% 2017 ok; 71.7% 2016 9% over range)
• 25 to 30 percent lymphocytes  (25.6% 2017 barely in range; 18.9% 2016 6% under range)

looking for WBC count to get a starting point industry idea of what is high/normal etc...

• quest diagnostics uses 3.8-10.8  thousand/uL (7.0 2017 ok; 6.4 2016 ok)

On Tue, Mar 21, 2017 at 12:50 PM, wolf <wolf@amplifyroi.com> wrote:

http://www.amymyersmd.com/2015/11/10-signs-you-have-candida-overgrowth-and-what-to-do-about-it

10 Common Candida Symptoms

1. Skin and nail fungal infections such as athlete's foot, ringworm, and toenail fungus
2. Feeling tired and worn down or suffering from chronic fatigue or fibromyalgia
3. Digestive issues such as bloating, constipation, or diarrhea
4. Autoimmune disease such as Hashimoto's thyroiditis, Rheumatoid arthritis, Ulcerative colitis, Lupus, Psoriasis, Scleroderma, or Multiple sclerosis
5. Difficulty concentrating, poor memory, lack of focus, ADD, ADHD, and/or brain fog
6. Skin issues such as eczema, psoriasis, hives, and rashes
7. Irritability, mood swings, anxiety, or depression
8. Vaginal infections , urinary tract infections, rectal itching, or vaginal itching>
9. Severe seasonal allergies or itchy ears
10. Strong sugar and refined carbohydrate cravings

Do you think you have Candida overgrowth? Take this simple quiz to find out!

How do you test for Candida overgrowth?

IgG, IgA and IgM Candida AntibodiesBlood tests check for IgG, IgA, and IgM Candida antibodies in your blood, and can be performed at most any lab. High levels of these antibodies indicate that an overgrowth of Candida is present somewhere in the body and that your immune system is reacting to it.

Remember, Candida has the ability to suppress the immune system so it is important to ask your doctor to test your total IgG, IgA and IgM levels along with the Candida antibodies.  Low levels of total IgG, IgA or IgM could cause a false negative response to the Candida antibodies, meaning you have Candida but since your immune system is lowered, you are unable to produce a response and your blood test comes back negative. Since I see so many patients with suppressed immune systems, I find in my clinic that blood tests can often be negative even when the stool or urine tests are positive.

Complete Blood Count (CBC)Often, I will see clues on a CBC that let me know that yeast is present.  A low white blood cell count (WBC) has been associated with yeast overgrowth as well as a pattern of  high neutrophil and low lymphocyte count. While these are non-specific to yeast, after working with thousands of patients, I can tell you I see this pattern very frequently in those with Candida overgrowth.