Nitrous Oxide, MTHFR and Trouble - MTHFR.Net

• nitrous oxide is 'poison gas' for anyone with a B12 deficiency, MTHFR and/or COMT gene variants, chronic condition
• my holistic dentist knew i had MTHFR and to not dose me with nitrous oxide, but most dont know/care what MTHFR is if you told them
• it kills B12 and help shut down your methylation cycle (mine already struggling) and cascade into a dozen symptoms and function areas

takeaway:

• nitrous oxide ruins your methylation and is not recommended these scenario:
  
• MTHFR variant
• B12 deficient
• Methylfolate deficient
• Glutathione deficient
• any chronic condition


• What to Use Instead of Nitrous Oxide?  
• NuCalm  (see below) - talk to your dentist about it
• Caffeine Elimination  (see below) - might be good to advise patients to not drink coffee/caffeine before procedure

http://mthfr.net/nitrous-oxide-mthfr-trouble/2015/02/06/

Nitrous Oxide, MTHFR and Trouble

by Dr Lynch on February 6, 2015

...

This is what I teach in all my conferences, webinars, podcasts, radio shows, interviews, articles and in conversations.

My goal is to teach you, physicians and the public – and mainstream media – that there are SAFE EFFECTIVE PROVEN alternatives to things like nitrous oxide.

Given that – why use nitrous oxide? Especially since it is known to be very harmful to certain individuals.

Let's discuss this now.

youtube 17m video:  https://youtu.be/_RUR-pe5RaA

 

What Nitrous Oxide Does to Your Biochemistry
It messes up your methylation.

Period.

Look at the research – here is a snapshot of the some of the research I've read about nitrous oxide:

You're familiar with vitamin B12.

You know how important this vitamin is.

Now imagine if something came into your body and destroyed it – flat out.

Welcome, nitrous oxide.

Nitrous oxide is a known oxidizer of cobalamin which effectively destroys it unless there are adequate nutrients available to restore the cobalamin back to its active and effective state.

What does this mean?

It means that nitrous oxide takes your vitamin B12 in your body and ruins it. It ruins it so much that it cannot do its job.

Vitamin B12's job, as methylcobalamin, is VERY important. It sets the stage for methylation to occur – in tandem with methylfolate.

Methylfolate? What's that.

Methylfolate is what your MTHFR enzyme makes – and if you have the MTHFR polymorphism – and don't eat much in the way of uncooked leafy greens, then you are LOW in methylfolate as well.

Let's simplify it.

You need vitamin B12 as ready-to-go methylcobalamin.

You need your MTHFR enzyme working so your body can make methylfolate.

You need both methylcobalamin and methylfolate to support your methylation.

If you are lacking just one of them, your methylation cycle does not work.

Yes – there is a backup route – but the main methylation cycle shuts down significantly.

Breathing in nitrous oxide ruins your methylation.

Who is at Risk by Using Nitrous Oxide?

1. Dentists. They get first to second-hand gas all day long.
2. Surgeons, nurses, office staff. They get first to second-hand gas all day long.
3. MTHFR folks. If you have one or more of the C667T variant or a combination of the C677T + A1298C (like me). Single A1298C does not predispose much risk; however, two A1298C variants do.
4. Vitamin B12 deficient. Wow there are a lot of people in this category.
5. Methylfolate deficient. MTHFR or not – you may be deficient in methylfolate for various reasons.
6. Glutathione deficient. When B12 gets damaged, who do you think comes and helps it out? Right. Glutathione.
7. Pretty much any chronic condition/disease. Lyme, autism, down syndrome, autoimmunity, diabetes, acid reflux, inflammatory bowel disorders, pregnancy, breast feeding mothers and so on.

Why do I Feel More Pain But I'm Relaxed?
This is an odd one but one that can be explained easily if looking at what is happening.

Dopamine is the neurotransmitter which contributes to pain – one of them – not the only one.

The higher the dopamine, the more intolerant to pain one will be.

If one's methylation is messed up by something – say, I don't know – nitrous oxide, then their dopamine levels could increase.

Now if one's dopamine levels were already low, they may find themselves more attentive, alert and feel great during and afterwards.

However, if one's dopamine levels were normal to high, they will find themselves experiencing more pain, irritability and insomnia.

If a person has a MTHFR and COMT Met/Met variant, then you are really talking about increased pain from nitrous oxide.

Once again, it depends on the person.

When do I know if Nitrous Oxide was Bad for Me?
If you have had nitrous oxide in the past and you were:

• sloooow the rest of the day, it was bad.
• your mood sucked for quite some time afterwards
• you began experiencing numbness and tingling in your extremities – on both sides
• your memory began to suck or you flat out lost it (dementia set in)
• some new conditions and symptoms started popping up: fatty liver, insomnia, irritability, sadness

Now know that these signs and symptoms can be experienced immediately – or delayed by a day or two.

This is what makes nitrous oxide so dangerous.

The side effects can be s.u.b.t.l.e. and many times they are.

What to Use Instead of Nitrous Oxide?

• NuCalm: I learned about NuCalm from Carol. She left a comment below. She said it REALLY helped her calm down. I reviewed it and it looks very interesting. Talk to your dentist about it – or find one that uses it.
• Caffeine Elimination. Caffeine increases anxiety partially because it slows your COMT enzyme. If COMT enzyme is slowed, then your dopamine levels increase. If your dopamine increases too much, then you become anxious and stressed out. Cut the caffeine on procedure days. You can do it.

...

Ever read the Tapping Solution? It can be a real life-savior.

The Tapping Solution Works for Many.

Note: The above book recommendation is an affiliate link which credits me a dollar or so if you purchase it. I do thank you for your support. Do know that I recommend only because I believe in it, have used it successfully personally or – both.

Here is what I recommend for those breathing in nitrous oxide (including the health professionals prescribing it):

1. Active B12 with L-5-MTHF: This provides both methylcobalamin and methylfolate in an easy-to-dissolve lozenge. Simply place in your mouth or your patient's mouth prior to using nitrous oxide. This will replenish the B12 levels during the procedure. Use one afterwards as well. Note these recommendations prior to using – read this article.
2. Optimal Liposomal Glutathione: This protects your vitamin B12 – along with many other things. Did you know that if you are low in glutathione, your ability to deliver vitamin B12 to your cell is limited?! Just because your blood levels of B12 may 'look' fine – they actually may be elevated – but what counts is how much B12 is INSIDE your cell. Outside doesn't mean that much – unless it is low. Consider 1/4 teaspoon once a day away from food one week prior to the procedure, then 1 tsp the day of the procedure and continue with 1 tsp a day after that for a month. Then reduce and use as needed. This is one my most recommended supplements – and for very good reasons. I use it a couple/three times a week – and I take a tablespoon at a time. I certainly couldn't take that much when I started – I worked up.

Those are it. Just two for the general population.

Of course, you do need to read the article I cited above – to reduce the risk of side effects from methylfolate.

Now, if you are stressed or anxious, then you may need additional support.

A few common and highly effective ones:

1. Optimal Adrenal: As discussed earlier, adaptogens are key for reducing anxiety. Optimal Adrenal provides a few different key adaptogenic herbs and select nutrients for the adrenals. I use this when I am stressed out or anxious – which thankfully now – is very rare. I used to be insanely anxious. You should have seen my first conference presentation. I was shaking….
2. Optimal Liposomal Glutathione: Yes. This is key for reducing anxiety as well. It's an odd one but if you understand the science and hear/read patient testimonials, you'd get it.

Another key book you should read: Could It Be B12? An Epidemic of Misdiagnosis

Could It Be B12? Yes. Definitely.

This book is well-written, easy-to-read and very clinically relevant – for both docs and laypersons. I've read it – twice.

Nitrous Oxide for Labor and in the Delivery Rooms
NO!!

Are you kidding me?

Give the kid a chance.

If you damage the mother's vitamin B12 during delivery, guess what you are doing to the baby's vitamin B12?

Exactly.

Ruining it.

Baby's are undergoing MASSIVE amounts of methylation reactions – because they are still developing – quickly.

You have a pregnant mother breathing in nitrous oxide, then you are ruining the baby's methylation status.

Now – stress in the labor room is not recommended either as that restricts blood flow to baby which is obviously not good.

Reduce labor stress by doing the above recommendations as I have clearly outlined. Scroll up.

They work.