Genetics related to Gout! - the gout killer

https://www.thegoutkiller.com/gout-causes/is-gout-hereditary/

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Kidney Genes

• The SLC22A12 gene:  This is an important gene that controls how much uric acid gets "reabsorbed" by the kidneys, which leads to higher levels of uric acid in the blood, which is at the root of what causes gout.
• The SLC2A9 (GLUT9) gene:  Problems with this kidney gene can lead to as much as a 5% variation in blood uric acid levels, which would play a minor role in gout.
• The ABCG2 gene, the SLC17A3 gene, and the SLC17A1 gene:  Problems with these kidney genes can only lead to as much as a 1% variation in blood uric acid levels, which would play an even smaller role in answering "Is Gout Genetic?".

 

Other Genes

• The ADRB3 gene is jointly involved in the development of metabolic syndrome and hyperuricemia (too much uric acid in the blood, hence gout).
• The MTHFR gene is involved in how purines are synthesized, which affects uric acid levels and causes gout.
• Uromodulin, renin, the aldolase B (ALDOB) gene and hypoxanthine-guanine phosphoribosylpyrophosphate (HPRT) are individual genes that, when mutated, do cause hyperuricemia, which leads to gout.  However it is noted that these single gene mutations are very rare, and are of little consequence when answering the question "Is Gout Genetic".

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