wolfnotes video: MTHFR Blood Indicators & How to start supplementing - YouTube - Dr.

https://www.youtube.com/watch?v=hJMl7Py2FRE

(Published on Apr 13, 2017)  Carolyn Ledowsky ND

wolfnotes:  transcribing the high points as i watch 

MTHFR

Rs 1801131  a1289c 

Rs 1801133  c677t  

avoid Folic-Acid + Calcium Folinate: its in most commercial bread/grain/pasta/cereals, so the advise is to eat GlutenFree bread/grain/pasta/cereals (or specialty bakers).

read the labels and avoid:  folic acid, calcium folinate, 5-formyltetrahydrofolate 

how to decide if you need to get tested for MTHFR

high RBC Folate

B12 <358

MCV > 90

RDW > 13%

if Hcy outisde the 7-8 umol range

high GGT

low vit A,D,E,K

low or high blood pressure

low T4

B1,2,3,5,6,7 cofactors key, so created starter B to provide these cofactors

B12 symptoms

44:28 MS-like symptoms may well have been B12 deficiency

B12 current normal reference range

500-1300 pg/mL japan has the highest range 

3 types of active B12:  methyl B12, hydroxy B12, adenosyl B12 

chewable: direct into mucosa bypass gut

supplementation regime:  starter b (123567), b12 for month, then slowly add methyl folate b9 in quarter increments, then add total b +400 methyl folate +400 methyl cobalamin

*presumably you swap starter b out and replace with total b +400 methyl folate +400 methyl cobalamin vs add total b atop starter b 

55:00  side fx of methyl folate

56:00  can be hard to notice, symptoms/mood can come on quickly or be insidious

Do you have the COMT gene?

Do you have issues with the CBS pathway?  If so address first:

• sulfur sensitivity
  
• elevated ammonia
  
• low glutathione
  

Specific SNPs to consider:

• CBS
  
• SUOX
  
• NOS
  
• CTH
  
• BHMT08
  
• FUT2
  

if you hit a wall overdose on B9 methyfolate, unbearable headache/depression etc, stop B9, and start B3 niacin every hour until back to normal.

considerations

thyroid function:  lack of T4 = lack of B2

gut:  may be increasing gluatmates, decreasing GABA, increasing amonia

estogen metabolism:  elevated estogen will affect neurotransmitters

questions

Q. havent tried anything yet, scared

A. starter B+B12 are safe, wont affect mood, but do know if/when to add folate